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Depakote Lawsuits

Depakote Limb Reduction Defects

What are Limb Size Reduction Defects?

Upper and lower limb reduction defects occur when a part of or the entire arm (upper limb) or leg (lower limb) of a fetus fails to form completely during pregnancy. The defect is referred to as a “limb reduction” because a limb is reduced from its normal size or is missing. CDC estimates that each year about 1,500 babies in the United States are born with upper limb reductions and about 750 are born with lower limb reductions . In other words, each year about 4 out of every 10,000 babies will have upper limb reductions and about 2 out of every 10,000 babies will have lower limb reductions. Some of these babies will have both upper and lower limb reduction defects.

Causes of Limb Reduction Defects

The cause of limb reduction defects is unknown. However, research has shown that certain behaviors or exposures during pregnancy can increase the risk of having a baby with a limb reduction defect. These including exposure of the mother to certain chemicals or viruses while pregnant, and exposure of the mother to certain medications, such as antiepileptic drugs including Depakote, Depakene, Depakote ER, Depakote Sprinkle, Divalproex Sodium, Valproate Sodium and Valproic Acid. Certain sets of limb reduction defects may be associated with other birth defects, such as neural tube defects (spina bifida), cleft palate, heart defects, omphalocele, and gastroschisis.

Complications of Limb Reduction Defects

Babies and children with limb reduction defects will face various issues and difficulties, but the extent of these will depend on the location and size of the reduction. Some potential difficulties and problems include:

  • Difficulties with normal development such as motor skills
  • Needing assistance with daily activities such as self-care
  • Limitations with certain movements, sports, or activities
  • Potential emotional and social issues because of physical appearance

Treatment of Limb Reduction Defects

The overall goal for treatment of limb reduction defects is to provide the child with a limb that has proper function and appearance. Specific treatment for limb reduction defects will be determined by the child's doctor, based on things like the child’s age, the extent and type of defect, and the child’s tolerance for certain medications, procedures and therapies. Treatment can vary for each child. Potential treatments include:

  • Prosthetics (artificial limbs)
  • Orthotics (splints or braces)
  • Surgery
  • Rehabilitation (physical or occupational therapy)

Prevention of Limb Reduction Defects

While no clear preventative measure has been identified, a woman taking multivitamins before she gets pregnant might decrease her risk for having a baby with limb reduction defects, although more research is needed. There is no known way to prevent this type of defect, but some of the problems experienced later in life by a person born with a limb reduction defect can be prevented or screened if the defect is treated early.

Prognosis of Limb Reduction Defects

It is important to remember that some babies and children with limb reductions will have some difficulties and limitations throughout life, but with proper treatment and care they can live long, healthy, and productive lives.

Speak to a Depakote Lawyer

The Willis Law firm has represented clients in Pharmaceutical Product Liability and Personal Injury litigation for over 25 years. We thoroughly understand the pharmaceutical industry and pharmaceutical product-liability drug litigation. You are not alone. If your child was born with Spina Bifida or other major congenital neural tube and skeletal malformations that may have resulted from your being prescribed and taking Depakote during pregnancy, please contact our law firm immediately to discuss your legal options. Please keep in mind that certain states have a statute of limitations regarding the amount of time you have to seek legal action.

The Willis Law Firm has been responsible for recovering significant settlements and verdicts for our clients. Financial recoveries can never bring back a loved one, but can help families deal with the financial stress associated with a life-changing injury or illness. They may also help prevent similar injuries to others in the future by holding pharmaceutical companies responsible today. Consulting a skilled and experienced pharmaceutical products-liability attorney is your first step in receiving the justice you and your family deserve. Contact us today for a free and confidential Depakote Side Effects lawsuit evaluation.

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Child's Injuries (check those that apply)

Spina Bifida
Neural Tube Defects
Facial Dysmorphism
Hand and Arm Deformities
Congenital Heart Defects
Craniofacial Deformities
Cleft Palate
Other Injuries (explain in detail below)
None of the Above


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